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pentobarbital will decrease the level or effect of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or outcome of flurbiprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.Human details. In the 29-year epidemiological review of 9,136 sufferers who were a